Signs and Symptoms

What are the signs and symptoms of tuberous sclerosis complex (TSC)?

The affects of TSC varies from mild to severe. Symptoms differ from patient to patient, depending on which organ systems are affected, and can include:

  • Neurological symptoms include seizures, developmental delays, autism spectrum disorders, obsessive compulsive-disorder and other behavior problems.
  • Tumors in the heart can cause circulation problems.
  • Skin symptoms include:
  • White pigment-less spots on the skin also called ash-leaf spots or hypomelanic macules
  • Rough, thick skin patches found on the back or back of the neck called shagreen patches
  • Tumors that grow in or around the beds of fingernails and toenails called ungal or subungal fibromas
  • Tumors in the kidney are common, but usually do not cause symptoms until the teen years.