Anna and John J. Sie Center for Down Syndrome

Contact Info

Sie Center for Down Syndrome
(720) 777-6750
(720) 777-7936

The Anna and John J. Sie Center for Down Syndrome at Children's Hospital Colorado was established thanks to a generous gift from the Anna and John J. Sie Foundation. The clinic officially opened its doors in November 2010 as part of the Linda Crnic Institute for Down Syndrome at the University of Colorado School of Medicine.

Care, information and resources for our community

The Sie Center for Down Syndrome provides the highest quality of comprehensive care to children with Down syndrome by coordinating medical care, along with therapies including speech, physical and occupational. We also serve as a local and national resource for families and primary care doctors by providing up-to-date information while also supporting parents who have received a prenatal diagnosis of Down syndrome.

Get the facts about Down syndrome.

Why choose the Anna and John J. Sie Center at Children's Hospital Colorado?

The Sie Center provides the best medical and therapeutic intervention available for children with Down syndrome in Colorado and surrounding states. As part of the Linda Crnic Institute, the Sie Center helps advance the total care of children with Down syndrome by providing excellent medical care, therapy, research and advocacy.

What makes our program unique?

Our team of providers has more than 80 years of combined experience in caring for children with Down syndrome and developmental disabilities. We have some of the top pediatric specialists in the nation who are actively involved with teaching at the University of Colorado School of Medicine, which in 2013 was ranked in the top 10 nationally by U.S. News & World Report. At Children’s Hospital Colorado we collaborate with premier pediatric sub-specialists in the country to improve the care of children with Down syndrome and develop state-of-the-art research. 

In addition, we’re working toward becoming a leading translational research program for children with Down syndrome. That means the Sie Center will take cutting-edge discoveries straight from our research lab and use them to help patients. Learn more about research at Children’s.

Services offered for children with Down syndrome

At the Sie Center, our services include evaluation, consultation and therapies for infants, children, teens and young adults with Down syndrome. We see patients from the prenatal phase of life, up to age 21. By coordinating our care with other clinics at Children's Hospital Colorado, we have an entire team of pediatric specialists working together to provide the best possible care for your child. 

Watch a video about Down syndrome and a local fundraiser that raises awareness.

What to expect for your visit


Prior to your first appointment, we will contact you to review your child’s and family’s needs. When you come to the Sie Center for Down Syndrome at Children’s Colorado, our multidisciplinary team will meet with your family and child. A developmental pediatrician or pediatric nurse practitioner along with therapists which may include physical therapist, speech therapist, feeding therapist, occupational therapist and social worker that will work together to assess your child. A registered dietitian is also available for consultation at certain appointments.  Meet the team at the Sie Center.


At the conclusion of the visit, your family will receive appropriate and up-to-date information, as well as resources and recommendations to optimize your child’s development and medical care. We will also share this information with your child’s primary care doctor.

Lastly, we’ll arrange periodic follow-up appointments based on your child’s needs and your parental concerns. To help make your visit to Children’s as convenient as possible, we will try to coordinate combination appointments with other sub-specialists during the same visit or over a period of a few days.

Get resources and more information.

Care from experts throughout the hospital


Through the Sie Center, your child receives a full spectrum of care from experts right within our hospital. Appropriate referrals will be recommended as well as testing. As part of our multidisciplinary approach to care, the Sie Center works closely with other departments at Children’s Colorado to coordinate care for your child such as: