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Researchers at Children’s Hospital Colorado have completed the first-ever Ex Utero Intrapartum Treatment (EXIT) to ventricular pacing procedure. The patient, a 36-week fetus, who suffered from complete atrioventricular block (CAVB) and cardiac dysfunction, was at high risk of dying before delivery. While still attached to its mother via the umbilical cord, the baby received a temporary pacemaker, which stabilized its dangerously low and irregular heart rate and ensured enough blood flow from the heart to the rest of its body for delivery.
“In essence, this procedure gave the fetus the gift of time,” said Bettina Cuneo, MD, fetal cardiologist. “Not only were we able to expose the heart and attach the pacing leads to make the heart rate faster, we were able to make sure the heart was functioning effectively before cutting the umbilical cord.”
A team of experts led by Dr. Cuneo and Henry Galan, MD, maternal fetal medicine at the hospital’s Colorado Fetal Care Center, worked with a multi-disciplinary team including Max Mitchell, MD, cardiothoracic surgery, to perform the procedure, and the infant was successfully delivered. Their research was recently published in Fetal Diagnosis and Therapy.
The risk of perinatal death in the first day of life is six-to-eleven times higher if a fetus:
This approach should significantly lower this increase in mortality for a preterm fetus with these conditions. “With the mother’s body acting as a heart and lung bypass machine, the EXIT procedure allows life-saving fetal interventions while maintaining in-utero circulation,” said Dr. Galan. “Although careful selection of patients is necessary, this ‘rescue’ pacing not only provides an option for the most fragile patients with CAVB, but also for fetuses who are at high risk for in-utero loss of life but are too premature for delivery.”