About the Pediatric Blood and Marrow Transplant and Cellular Therapy Program
When your child needs a blood or bone marrow transplant or cellular therapy treatment, you want to find the best care possible. That’s why our Pediatric Blood and Marrow Transplant and Cellular Therapy Program team is committed to the highest standards of quality, the latest and most proven treatments, and the overall care and well-being of your child and family.
Our team is the region's most experienced pediatric blood and marrow transplant and cellular therapy (BMT) program. We have performed more than 1,100 bone marrow transplants and have a growing cellular therapy program offering new, effective and less toxic therapies for a variety of diseases. Our providers specialize in pediatric blood and marrow transplants and cellular therapy, so you can trust that your child is in good hands.
Our BMT Program has been continuously accredited by the Foundation for Accreditation of Cellular Therapy (FACT) since 2001. This certification is granted to a limited number of hospitals and is based on patient outcomes, patient volumes, qualified staff, appropriate facilities and having a comprehensive quality assurance program that meets current national FACT standards. The standards indicate that our transplant team has been consistently recognized through national peer review for high-quality patient care and laboratory performance for bone marrow transplant.
10Years of our program meeting or exceeding international standards (out of 10 years evaluated)
28+Years of pediatric bone marrow transplant experience
Cutting-edge cellular therapy
Our pediatric specialists offer a range of cellular therapy options, including chimeric antigen receptor (CAR) T cells and virus-directed T cells. T cells are a type of white blood cell that develop from stem cells in the bone marrow. They help fight infection and can fight cancer.
CAR-T cells: For this type of cellular therapy, we draw blood from a patient to collect circulating T cells, which are an important part of the body’s immune system. Next, using a non-contagious virus, we genetically engineer these T cells to make specialized proteins on the T cell surface. These engineered T cells, called CAR-T cells, are capable of recognizing certain cancer cells. The CAR-T cells are then infused back into the patient and attach to specific proteins on the surface of cancer cells. The CAR then triggers the T cells to kill the cancer cell. Our team has extensive experience with both commercially available and locally manufactured CAR-T cells, and we can safely manufacture new types of CAR-T cells that are not available elsewhere.
Virus-directed T cells: After a bone marrow transplant, it takes a while for the new immune system to recognize cells that are infected with certain viruses. Often, viruses from the Herpesvirus family, which are known to cause diseases such as mononucleosis (“mono”), upper respiratory tract infections, cold sores and roseola, never fully go away after the first infection. Rather, the immune system keeps them at bay.
When the immune system is recovering after a bone marrow transplant, these viruses can cause significant infections, which sometimes lead to very severe complications for a bone marrow transplant patient. Similar to the development of CAR-T cells, we can use engineered T cells from the blood of the stem cell donor or another individual to produce cells that recognize the virus-infected cells and kills them. This therapy can be lifesaving for people with these types of infections.
Who we treat at the Pediatric Blood and Marrow Transplant and Cellular Therapy Program
We treat patients from birth to 26 years old who could benefit from a blood and marrow transplant or cellular therapy.
Specialized BMT care for teenagers and young adults
Research has shown that teens and young adults with cancer do better when treated on pediatric protocols and in a pediatric setting. Stem cell sources and therapy regimens often differ between adult and pediatric institutions and may affect outcomes. Additionally, pediatric oncologists and bone marrow transplant specialists are more experienced with managing any potential long-term complications after therapy.
What does our Pediatric Blood and Marrow Transplant and Cellular Therapy Program offer?
Our multidisciplinary BMT program includes:
Consultation, evaluation, treatment and follow-up care
BMT-trained pediatric physicians, nurse practitioners and physician assistants
Board-certified pediatricians and pediatric hematologists/oncologists
Pediatric radiation oncologists
Dedicated, BMT-trained nursing staff
Dedicated pediatric BMT-trained pharmacists
A HEPA-filtered, positive pressure 24-bed inpatient BMT unit with the capacity to expand to 48 beds when needed
Transplant coordinators who guide patients and advocate for them through the entire transplant experience – coordinating care from entry into the Program through transition back to the primary care provider
BMT-specific outpatient team and clinic services
Fertility preservation services
Palliative care services focused on symptom management, quality of life and how you or your child is best treated
Technology and on-site facilities to procure and process stem cells from marrow, peripheral blood and cord blood
Availability of both autologous (a patient's own stem cells) and allogeneic (another person as the donor stem cells) transplant methods and expertise
Numerous state-of-the-art local, national and international clinical trials in pediatric hematopoietic stem cell transplant and investigational drug availability
Care within the context of a large, highly specialized pediatric academic medical center with all sub-specialties on site and available throughout the transplant care
Pediatric bone marrow transplantation and cellular therapy research and innovation
Members of our team are actively involved in pediatric bone marrow transplant and cellular therapy research with the goal of improving outcomes in children. Our team performed its first cord blood transplant in 1996, early in the investigation of this now common stem cell source. Today, our ongoing research projects focus on optimizing the success of BMT for many pediatric disorders in cancer, immunodeficiencies, sickle cell disease and rare metabolic conditions.
Our team members are committed to providing excellent service to patients and providers through an efficient call-back and evaluation for urgent referrals. Streamlined communication occurs before, during and after transplantation. Our expert team is regularly consulted by providers around the country and the world for the specialized care that we can deliver here. Get more information for healthcare professionals or apply to our hematology oncology and BMT fellowship.
Compassionate care, wherever you are
We’re here when you need us. Telehealth appointments are available across every specialty, so you can get the high-quality care we’ve always offered from the comfort, privacy and convenience of home.
Whether your child has a known diagnosis or you’re still looking for answers, our pediatric cancer and blood disorder specialists can help. We provide second opinions for many conditions so you can feel confident about your child’s treatment.
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Children's Hospital Colorado providers
Children’s Hospital Colorado providers are faculty members of the University of Colorado School of Medicine. Our specialists are nationally ranked and globally recognized for delivering the best possible care in pediatrics.
Some healthcare professionals listed on our website have medical privileges to practice at Children’s Hospital Colorado, but they are community providers. They schedule and bill separately for their services, and are not employees of the Hospital.