Children's Hospital Colorado

Monoclonal Antibody Treatment for Children with COVID-19

At Children’s Hospital Colorado, we treat the big things, the small things and everything in between.

What is COVID-19 monoclonal antibody treatment?

COVID-19 monoclonal antibody (sometimes shortened to mAb) therapy is a promising new treatment for certain patients with mild or moderate COVID-19. This therapy should not be used as a replacement for COVID-19 vaccination, which is the strongest protection available against the new coronavirus.

Monoclonal antibodies can help prevent severe illness for some people who get sick with COVID-19. COVID-19 monoclonal antibody treatment is available for people who:

  • Have tested positive for COVID-19
  • Have mild to moderate symptoms
  • Are at high risk of developing severe illness

At Children’s Hospital Colorado, we offer a limited number of weekday mAb treatment appointments at our hospital on Anschutz Medical Campus in Aurora. Appointments are available to eligible pediatric patients only. (Current adult patients who receive care from one of our specialty teams, such as oncology, may also be eligible.) Because supply is extremely limited, we are prioritizing patients at highest risk of COVID-19.

We encourage parents to speak to their child’s primary care provider or specialty care team at Children’s Colorado to understand whether their child is eligible and make a referral. Parents and guardians can also self-refer eligible children for treatment through this web page.

How mAb works

Who is eligible for monoclonal antibody therapy at Children's Colorado?

There are strict criteria for monoclonal antibody therapy and timing. Not everyone will be eligible. While parents can refer their eligible children, we encourage you to work with your primary care doctor to learn if the treatment is appropriate for your child and to get a physician referral.

Patients must meet each of the following criteria to be eligible for monoclonal antibody treatment at Children’s Colorado:

  • Be 12 years old or older
  • Weigh at least 88 pounds (40 kilograms)
  • Have mild to moderate symptomatic COVID-19, but not requiring hospitalization or oxygen or respiratory support due to COVID-19
  • Have a positive COVID-19 viral test (PCR or antigen)
  • Considered high-risk for progressing to severe disease with COVID-19
  • Get treated within 7-10 days of symptoms starting (depending on the treatment)

What’s considered mild or moderate COVID-19?

Mild to moderate COVID-19 is defined as having symptoms consistent with COVID-19 (such as runny nose, cough, congestion, fevers, etc.) but not needing hospitalization or oxygen support (new or increase in baseline oxygen) due to COVID-19.

What are considered high-risk conditions?

High-risk conditions for children include:

  • Immunosuppressive disease or receiving immunosuppressive treatments
  • Diabetes
  • Chronic kidney disease
  • A body mass index (BMI) more than or equal to 35
  • BMI more than or equal to the 85th percentile for age and gender
  • Sickle cell disease
  • Congenital or acquired heart disease
  • Neurodevelopmental disorders
  • Medical-related technological dependence (such as tracheostomy or G-tube)
  • Asthma, reactive airway disease, or other chronic respiratory diseases that requires daily medication for control

Patients who don’t meet these criteria and don’t belong to one of these high-risk groups are not eligible to receive monoclonal antibodies. Patients must also be treated within 10 days of their symptoms starting as these medications are unlikely to be helpful after that time.

None of the monoclonal antibody products are approved for use in children or adults who are hospitalized due to COVID-19 or who need new or increased oxygen requirements. This is because current evidence doesn’t conclusively show a benefit for patients hospitalized for COVID-19.

How to request monoclonal antibody treatment at Children's Colorado

  1. If you believe your child is eligible, submit their information at the link below. (Your doctor can also refer your child through this form.)
  2. Our infectious disease team will review your children's information. If they are eligible and appointments are available, our team will contact you to ask you additional screening questions.
  3. If we determine that your child is eligible for monoclonal antibody treatment during the phone screening, we will help you make an appointment.

Please note: Phone screening and infusion visits happen during normal business hours from Monday through Friday only. We may not be able to accommodate all children who meet the criteria for initial screening due to the limited capacity and availability of the drug.

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What to expect

Frequently asked questions

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Editor's note: This page was updated on March 14, 2022. Due to the evolving nature of the coronavirus pandemic, recommendations can change quickly. Please follow all rules and guidelines set by state and local public health and safety authorities. Reference CDC and CDPHE for immediate updates on COVID-19.