- Doctors & Departments
- Conditions & Advice
- Your Visit
- Research & Innovation
The Cardiopulmonary and Vascular Biology emphasis area integrates several well-established and successful programs and laboratories that utilize multidisciplinary approaches towards developing a greater understanding of basic mechanisms and therapies for the treatment of diverse cardiac, pulmonary and vascular diseases in newborns, infants and children.
The overall purpose of this group is to promote basic and translational research and to develop and apply novel strategies that will enhance outcomes of children with cardiopulmonary and vascular disorders. Key goals are to facilitate and co-ordinate new program development; provide an “academic home” that will create an environment to enhance mentorship, training and career development opportunities for students, residents, fellows and faculty; establish critical core laboratories to enhance patient- and laboratory-oriented research; expand educational opportunities through integrative seminars, courses and symposia; and to more effectively link investigators from diverse disciplines to encourage further development of novel programs based on principles of “team science.”
This group incorporates strengths from current programs that link clinical care, clinical research, laboratory research, education and training. Current themes of ongoing clinical and laboratory research include: basic mechanisms of angiogenesis and vascular development; the influence of vascular growth on lung structure; epigenetic mechanisms of pulmonary vascular disease; the pathobiology of pulmonary hypertension, including vascular inflammation; roles of progenitor cells in vascular development, disease and therapies; novel assessments of right ventricular function, especially in the setting of pulmonary hypertension; the epidemiology and natural history of pulmonary vascular disease in preterm infants; clinical response to drug therapy in chronic pulmonary hypertension; and the development of novel vascular therapies to promote fetal health and prevent premature birth.
Leader: Kurt R. Stenmark, MD
Professor of Pediatrics and Medicine
Division Head, Pediatric Critical Care Medicine
Director, Developmental Lung Biology and
Cardiovascular Pulmonary Research Laboratories
University of Colorado Denver