Children's Hospital Colorado

Q: Advances and Answers in Pediatric Health

By prioritizing and advancing research, education, clinical work and process improvement, we're speeding the integration of our discoveries into the clinical engine, helping patients in new and innovative ways. A unique and strong partnership with University of Colorado Anschutz Medical Campus provides fresh perspectives and invaluable expertise, as do our relationships with national and international research consortiums, industry partners and other children's hospitals.

It starts with a Q:

Like the kids we treat at Children's Hospital Colorado, we're creating a culture that continuously inspires curiosity. Doing so unlocks a new realm of pediatrics — one that swaps insular science and medicine for collaborative, progressive approaches to accelerating discovery.

Questions once asked within the silos of specific specialties are more and more commonly being addressed across multidisciplinary planes. These approaches are producing remarkable advances because here, we imagine the future and simultaneously create it.

Q: A research and innovation magazine 

Q: is a quarterly magazine where we highlight some of our groundbreaking research and innovations, featuring the many ways our clinicians work together and across specialties to continually improve patient care and outcomes.

Read some of the latest articles from our current issue. You can also access full digital versions of all Q: magazine issues at the bottom of the page.


Stopping the vicious inflammatory cycle of ARDS

Fetuses don’t scar. That insight led fetal and pediatric surgeon Dr. Kenneth Liechty and his research team deep into an investigation of the inflammatory response. The result was a two-pronged treatment that’s producing impressive results in disease processes that hinge on inflammation, including acute respiratory distress syndrome, the leading cause of death in COVID-19.

Q: Can a fetal surgeon’s treatment for diabetic wounds reduce mortality in severe COVID-19?

Dr. Liechty speaking with another researcher.
Cartoon image of a molecule

Severe OTC deficiency disorder: a case study

The family had already lost two children to severe ornithine transcarbamylase (OTC) deficiency disorder, a full deletion of a gene that plays a key role in clearing ammonia from the body. The first was misdiagnosed. The second was diagnosed correctly, but the damage was already done. When the mother became pregnant a third time, a team of specialists at Children’s Hospital Colorado had a plan.

Q: Could treatment from before birth stave off a deadly disease until transplant?

Headshot of Dr. MicKinney

Specialists perform a bone marrow transplant without third-party red blood cell donor

A 15-month-old patient has two rare disorders. Primarily, chronic granulomatous disease, or CGD, an immunodeficiency disease that affects the body’s ability to protect against bacterial infection. Secondarily, McLeod syndrome, a neurological disorder that causes abnormal RBCs and potentially impairs cardiovascular and nervous system function. The cure for CGD is a bone marrow transplant, but McLeod syndrome makes it nearly impossible to find a compatible blood donor to support the transplant.

How do you perform a bone marrow transplant without using red blood cells from a third-party match?

Dr. Vijaya

Standards of care for fetal genitourinary (GU) anomalies

Children’s Colorado has steadily worked to build a comprehensive, multidisciplinary care program for fetal genitourinary, or GU, anomalies. In fact, the program made Children’s Colorado a prime candidate for Johns Hopkins’ Renal Anhydramnios Fetal Therapy (RAFT) multicenter clinical trial. The RAFT trial is evaluating interventions for early pregnancy renal anhydramnios, or EPRA, a condition in which a pregnant woman lacks amniotic fluid around her fetus due to a problem with the fetus’ kidneys.

Q: How do you safely build standards of care for an emerging field of medicine?

Dr. Di Maria profile image

Fontan circulation flow propagation: 3 studies

The three operations that reroute circulation for kids with hypoplastic left heart syndrome have saved thousands of lives. But they’re far from a perfect solution, and while some do better than others, little is known about how or why. Our researchers are studying the downstream effects of Fontan circulation using novel measurements derived from 4D flow MRI — and they’re uncovering some fascinating correlations.

Q: What can 4D MRI reveal about single ventricle flow patterns and how they correlate to clinical outcomes?

Recent issues of Q:

Access full digital versions of Q: magazine to learn how our clinicians work together and across specialties to continually improve patient care and outcomes.

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