Children's Hospital Colorado

Q: Advances and Answers in Pediatric Health

By prioritizing and advancing research, education, clinical work and process improvement, we're speeding the integration of our discoveries into the clinical engine, helping patients in new and innovative ways. A unique and strong partnership with University of Colorado Anschutz Medical Campus provides fresh perspectives and invaluable expertise, as do our relationships with national and international research consortiums, industry partners and other children's hospitals.

It starts with a Q:

Like the kids we treat at Children's Hospital Colorado, we're creating a culture that continuously inspires curiosity. Doing so unlocks a new realm of pediatrics — one that swaps insular science and medicine for collaborative, progressive approaches to accelerating discovery.

Questions once asked within the silos of specific specialties are more and more commonly being addressed across multidisciplinary planes. These approaches are producing remarkable advances because here, we imagine the future and simultaneously create it.

Q: A research and innovation magazine 

Q: is a quarterly magazine where we highlight some of our groundbreaking research and innovations, featuring the many ways our clinicians work together and across specialties to continually improve patient care and outcomes.

Read some of the latest articles from our current issue. You can also access full digital versions of all Q: magazine issues at the bottom of the page.

 

Dr. Hsieh profile image.

A multi-omics database for COVID-19 research

Elena Hsieh, MD, saw a need for widely accessible, analysis-ready datasets. So she and her research team built a user-friendly research portal that makes it easy to do multi-omics analyses for COVID research projects. They call it the COVIDome, and between launch in November 2020 and June of 2021, the dashboard saw more than 800 unique users from 36 countries around the world.

Q: How do you make it easy to do multi-omics analyses for COVID research?

Person performing CPR

A simulation for pediatric cardiac arrest

CPR is pretty simple in theory. In practice, though, it’s well known that the actual effectiveness of CPR declines almost immediately after training. Thanks to a five-minute training implemented in 2016, our emergency department maintains a 97% resuscitation rate for cardiac arrest. It’s so effective, in fact, that when COVID-19 came along and changed the entire procedure, the resuscitation team didn’t miss a beat.

Q: Could a low-fidelity cardiac resuscitation simulation help prepare teams for COVID-19?

Researcher examining a glass bottle.

Clinical trial: dual-attack CAR T-Cell therapy for pediatric acute lymphoblastic leukemia

In about half of cases of acute lymphoblastic leukemia treated with CAR T-cells, the cancer cells mutate to lose CD19, the surface protein the CAR T-cells target. Some researchers have tried targeting another surface protein, CD22, after relapse, with success. Researchers at Children’s Colorado are preparing to trial a CAR that targets both proteins on the first go.

Q: Can a new protein target improve the durability of CAR T-cell therapies?

Woman using a virtual reality apparatus.

Virtual reality for cardiac catheterization in children

A cath lab’s job generally falls into two broad buckets: diagnostic, where the team measures pressures, gathers samples or sets up contrast imaging; and interventional, where the team places a device. In the Cardiac Catheterization Program at Children’s Colorado, pediatric interventional cardiologists Jenny Zablah, MD, and Gareth Morgan, MD, are leveraging the power of virtual reality for both.

Q: Can a futuristic set of goggles help improve outcomes and shorten procedure times?

Recent issues of Q:

Access full digital versions of Q: magazine to learn how our clinicians work together and across specialties to continually improve patient care and outcomes.

Past issues of Q:

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