Children's Hospital Colorado

Perinatal Clinical Translational Research Center

About the Perinatal CTRC

The Perinatal Clinical Translational Research Center (CTRC) was formed in 2008 as part of the new Colorado Clinical and Translational Sciences Institute (CCTSI) and was a transformation of the former General Clinical Research Center (GCRC) that was first developed in 1979. The Perinatal CTRC provides specialized nursing support to investigators conducting research in the NICU, Newborn Nursery, and Labor and Delivery areas.

The Perinatal CTRC research nurses work at University of Colorado Hospital (UCH), Children’s Hospital Colorado (Children's Colorado), Exempla St. Joseph Hospital (ESJH) and Denver Health Medical Center. The Perinatal CTRC Scatterbed Unit is available 24/7 and maintains offices at Children's Colorado and UCH. It includes laboratory space adjacent to the UCH NICU and within the Children's Colorado NICU.

Neonatal intensive care unit (NICU) experienced nurses are available to provide expert clinical research support during protocol development, implementation, and data collection. The Perinatal scatterbed nurses go to the subject-patient’s bedside to conduct the research protocol. The scatterbed concept is the only safe and ethical manner in which to enroll newborn infants and their pre- or postpartum mothers into research studies due to the sometimes tiny size of preterm infants and their complex medical care and the unique settings in which mothers deliver babies.

Perinatal protocols have included research focused on intrauterine growth restriction, extremely low birth weight, pulmonary hypertension, respiratory failure and the prevention of BPD in neonates, pre-eclampsia, premature rupture of membranes, HIV, growth and nutrition as well as lactation.

Summary of services

CTRC nursing team

The Perinatal CTRC Nursing Team is renowned for their knowledge and success in conducting studies. The Perinatal CTRC provides:

  • Five NICU experienced Registered Nurses with extensive experience caring for participants in complex research protocols,
  • Two Health Care Technicians who work closely with the nursing staff to assist with research procedures and processing of samples.

Specialized research services and equipment

  • Study drug administration
  • IV infusions
  • Bailey exams
  • PeaPod
  • Refrigerated centrifuge
  • -80 freezer
  • Hemopoint
  • GE Vivid 9 Ultrasound Machine
  • Cord blood collection & processing
  • Placental processing

The nurses are also continually developing new skills to meet the requirements of protocols

Multi-disciplinary role in the CCTSI

  • Nurse Administrator
  • Neonatal Intensive Care expertise
  • Protocol oversight
  • Staff and Investigator Support
  • Protocol Operations
  • Screening and enrollment
  • Data and sample collection
  • Participant follow-up
  • Clinical Expertise
  • Feasibility Assessments for Study Implementation

Working with the Perinatal CTRC

Once approval is obtained by COMIRB, SARC (for utilization of the Perinatal CTRC resources) and the HRRC, your protocol will be assigned to a research nurse liaison within the Perinatal CTRC. You will be requested to meet with the nurse to develop protocol guidelines, orders and data forms. Your liaison will be your main contact for the study duration if changes need to be made or problems arise with study implementation.

NIH Funding Acknowledgment

Important: Any publications, patents, projects, or other tangible outcomes that benefit from CCTSI resources are required to credit the CCTSI grant by including the NIH Funding Acknowledgment.