Children's Hospital Colorado

Diphenhydramine (Benadryl) Dose Table

Child's weight (pounds) 20-24 25-37 38-49 50-99 100+ lbs.
Liquid 12.5 mg/ 5 milliliters (mL) 4 5 7.5 10 -- mL
Liquid 12.5 mg/ 1 teaspoon (tsp) ¾ 1 2 -- tsp
Chewable 12.5 mg -- 1 2 4 tablets
Tablets 25 mg -- ½ ½ 1 2 tablets
Capsules 25 mg -- -- -- 1 2 caps

When to Use. Treatment of allergic reactions, nasal allergies, hives and itching.

Table Notes:

  • Age Limits. For allergies, don't use under 1 year of age. Reason: it causes most babies to be sleepy. For colds, not advised at any age. Reason: no proven benefits. It should not be given if under 4 years old. If under 6 years, don't give products with more than one ingredient in them (FDA recommendation 2008).
  • Dose. Find the child's weight in the top row of the dose table. Look below the correct weight for the dose based on the product you have.
  • Measure the Dose. Syringes and droppers are more accurate than teaspoons. If possible, use the syringe or dropper that comes with the medicine. If not, you can get a med syringe at drug stores. If you use a teaspoon, it should be a measuring spoon. Reason: regular spoons are not reliable. Keep in mind 1 level teaspoon equals 5 mL and that ½ teaspoon equals 2.5 mL.
  • Adult Dose. 50 mg
  • How Often. Repeat every 6 hours as needed.
  • Children's Benadryl Fastmelts. Each fastmelt tablet equals 12.5 mg. They are dosed the same as chewable tablets.
  • Use in Countries Outside the U.S. Dose tables are based on U.S. products. Concentrations may vary in countries outside the U.S. Always check the concentration is the same before using this dose table.


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