Children's Hospital Colorado

Q: Advances and Answers in Pediatric Health

By prioritizing and advancing research, education, clinical work and process improvement, we're speeding the integration of our discoveries into the clinical engine, helping patients in new and innovative ways. A unique and strong partnership with University of Colorado Anschutz Medical Campus provides fresh perspectives and invaluable expertise, as do our relationships with national and international research consortiums, industry partners and other children's hospitals.

It starts with a Q:

Like the kids we treat at Children's Hospital Colorado, we're creating a culture that continuously inspires curiosity. Doing so unlocks a new realm of pediatrics — one that swaps insular science and medicine for collaborative, progressive approaches to accelerating discovery.

Questions once asked within the silos of specific specialties are more and more commonly being addressed across multidisciplinary planes. These approaches are producing remarkable advances because here, we imagine the future and simultaneously create it.

Read the latest articles from our current issue of Q: and find all past issues below.

Fetal surgeon Dr. Liechty takes on congenital anomalies at Children's Hospital Colorado.

Dilation complication

Timing the delivery of a high-risk baby can be a delicate balance. That’s particularly true for gastroschisis, a congenital disorder in which some organs, most commonly the intestines, develop outside the abdominal wall.

Q: Can abdominal dilation predict complex gastroschisis?

Dr. Dempsey talking with a pregnant mother.

The mother whisperer

Fetal conditions are stressful. They interrupt families’ lives, put new demands on their time and finances, shatter their expectations of what parenthood might be.

Q: Can breathing mitigate the stress of a prenatal diagnosis?

Dr. Inge and Dr. Bjornstad talking in a hospital hallway.

The comeback kidneys

Treatment methods to impede diabetic kidney disease in obese youth with type 2 diabetes are largely ineffective, save for one: weight loss surgery. Endocrinologist Petter Bjornstad, MD, is working to find out why that is and if there’s a way to leverage its effects for patients who can’t have surgery.

Q: Why does bariatric surgery help protect the kidneys in severely obese youth with type 2 diabetes?

Dr. Nathan Donaldson with a patient who had a total joint replacement.

Joint venture

Outside of solid tumors, a total joint replacement is a rare surgery for adolescents. There isn’t a lot of information on outcomes for this age group, so our researchers are starting to collect it.

Q: What is postoperative life like for a kid who undergoes a total joint replacement?

Illustration of droplet technology based on Dr. Winters' research.

A drop in the bucket

Pediatric oncologist and hematologist Amanda Winters, MD, is using a special type of polymerase chain reaction (PCR) called digital droplet PCR, to more reliably identify measurable residual disease in acute myeloid leukemia.

Q: Is there a better way to identify measurable residual disease?

Dr. Scott Sagel treats a young child with CF.

A cystic fibrosis catch-22

A new therapy, Trikafta, approved by the FDA in late 2019, is a combination of three rescue therapies for the cystic fibrosis (CF) transmembrane conductance regulator, the defective protein that results from various CF mutations. It offers the best chance of improvement in protein function from zero in some cases to more than 50% of normal.

Q: Can Trikafta help a patient get a needed transplant?

Past issues of Q:

Download previous issues of Q: to learn how our clinicians work together and across specialties to continually improve patient care and outcomes.

Stay informed