Clostridioides Difficile (C. diff)

Children’s Hospital Colorado’s Clostridioides difficile clinical pathways provide guidance on the management of patients with Clostridioides difficile infections. The pathways: 

• Facilitate testing recommendations based on risk factors to avoid unnecessary interventions  
• Offer evidence-based treatment algorithms for those with confirmed infection based on the number of previous infections and illness severity 

Clostridioides difficile clinical pathway  

• Clostridioides Difficile | Inpatient 
• Clostridioides Difficile | Ambulatory 
• Clostridioides Difficile | Emergency Department/Urgent Care  

About our Clostridioides difficile clinical pathway 

The Clostridioides difficile clinical pathways offer best practice recommendations for patients with suspected and confirmed Clostridioides difficile infections. They were created by our multidisciplinary team of content experts including hospital medicine, infectious diseases, gastroenterology, critical care, pediatrics, oncology, pharmacy providers and process improvement professionals. Our teams reviewed available published literature and they integrated local expert opinion when necessary.  

These pathways offer a standardized approach to risk stratification, diagnosis, and management of Clostridioides difficile infections.