Children's Hospital Colorado

Digestive Health Institute Education Videos

Close-up view of a patient wearing a yellow-green ribbed shirt, lifted up to show the stomach, where a doctors' hands are pressing into one side Best Children's Hospital by US News Card Gastroenterology 2020-1 Badge

Our Digestive Health Institute physicians provide innovative diagnostic and therapeutic approaches in all aspects of pediatric gastrointestinal (GI), liver, pancreatic and nutritional disorders. We’re committed to improving the health, care and quality of life for children and adolescents with digestive health conditions in the region and nationally.

One of the ways we commit to improving the digestive health of all children is by sharing our novel approaches to care with other providers so they can improve care in their own communities. In the following videos, our providers will discuss groundbreaking digestive health research, diagnosis, treatment and more. Watch the provider education videos below to learn from our GI, hepatology and nutrition experts.

The creatine transporter is necessary for intestinal cell function and altered in inflammatory bowel disease (IBD)

Inflammatory bowel disease (IBD) can affect any part of the digestive system and is associated with a weakened intestinal barrier. In a recent study published by Digestive Health Institute, researchers found that creatine regulates energy distribution within intestinal epithelial cells (IECs) and reduces the severity of colitis in mice.

Pediatric gastroenterologist Caroline Hall, MD, PhD, discusses her investigation into the functions of the creatine transporter (CRT), in IECs and maintenance of the intestinal epithelial barrier. In an analysis of IEC cell lines and colonoids from CRT knockout mice, Dr. Hall and her team found CRT regulates energy balance in IECs, along with epithelial integrity and barrier function. Mucosal biopsies from patients with IBD have lower levels of CRT, which may contribute to the reduced barrier function observed in patients with Crohn’s disease or ulcerative colitis.