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A "presumptive positive" strongly indicates that the infant has congenital hypothyroidism. Specifically, the elevated TSH level and low T4 level identify infants with primary hypothyroidism due to thyroid dysgenesis or thyroid dyshormonogenesis.
Thyroid hormone is important for growth, development, and metabolism. It is also crucial for brain development in the first 2-1/2 to 3 years of life. Infants with congenital hypothyroidism left untreated will likely become mentally retarded.
You should check the TSH and total or free T4 level to confirm the diagnosis of congenital hypothyroidism. You should send this sample to a clinical laboratory to obtain an accurate value rather than sending the sample again to the newborn screening lab.
No. If you have a presumptive positive result, you should start treatment with thyroid hormone replacement as soon as possible and obtain a telephone consultation with one of the pediatric endocrinologists in Denver listed on the screening report you received.
There is a TSH surge shortly after birth and T4 levels subsequently increase within 1 day. In samples obtained within the first day of life, total T4 levels are normally lower and TSH levels are normally higher (up to 50 IU/L) and will be reported as abnormal on the newborn screen.
You should check the TSH and total or free T4 level to confirm the diagnosis of congenital hypothyroidism. You should send this sample to a clinical laboratory to obtain an accurate value rather than sending the sample again to the newborn screening lab. It is at your discretion whether to start thyroid hormone replacement therapy immediately or wait until the laboratory results return and the diagnosis is confirmed.
You should check the TSH and free T4 levels to distinguish between TBG deficiency and central hypothyroidism. If the free T4 level is low, contact a pediatric endocrinologist for further advice.
The newborn screening program was initially designed for infants who were discharged after 3 days in the hospital. With shortened nursery stays, there is a risk for missing some cases of hypothyroidism and the second screen was initiated. A recent study of Colorado's newborn screening program indicates that more than 10% of infants with congenital hypothyroidism are missed by the first screen.
If the infant has a confirmed diagnosis of congenital hypothyroidism, consultation with a pediatric endocrinologist is strongly encouraged. A Pediatric Endocrinologist can provide expert information to the parents about congenital hypothyroidism and the importance of thyroid hormone replacement to prevent mental retardation. Thyroid function will need to be reassessed throughout infancy and thyroid hormone doses will need to be adjusted as the infant grows. All infants with evidence suggesting central hypothyroidism should be evaluated by a Pediatric Endocrinologist to assess for associated hormonal abnormalities.
Francis Hoe, MD
Barbara Davis Center for Childhood Diabetes