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COVID-19 Vaccine Update
We're closely monitoring the emergency use authorization of the Pfizer COVID-19 vaccine for children ages 12 and older. As of May 11, individuals ages 12 to 15 can register to receive the Pfizer vaccine at Children's Colorado. However, they will not begin receiving invitations to make appointments until final recommendations are adopted by the CDC.
For complete COVID-19 resources, please see our resources for parents and families and resources for providers.
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Anschutz Medical Campus
13123 East 16th Avenue
Aurora, CO 80045
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Common Questions and Answers: Presumptive Positive Screen for Hypothyroidism
From a healthcare professional: I received a "presumptive positive screen" for hypothyroidism. What does this mean?
A "presumptive positive" strongly indicates that the infant has congenital hypothyroidism. Specifically, the elevated TSH level and low T4 level identify infants with primary hypothyroidism due to thyroid dysgenesis or thyroid dyshormonogenesis.
Why is congenital hypothyroidism important?
Thyroid hormone is important for growth, development and metabolism. It is also crucial for brain development in the first 2-1/2 to 3 years of life. Infants with congenital hypothyroidism left untreated will likely become mentally retarded.
What tests should I do?
You should check the TSH and total or free T4 level to confirm the diagnosis of congenital hypothyroidism. You should send this sample to a clinical laboratory to obtain an accurate value rather than sending the sample again to the newborn screening lab.
Should I wait for the test results before I start treatment?
No. If you have a presumptive positive result, you should start treatment with thyroid hormone replacement as soon as possible and obtain a telephone consultation with one of the pediatric endocrinologists listed on the screening report you received.
What are other causes of a "presumptive positive screen"?
There is a TSH surge shortly after birth and T4 levels subsequently increase within 1 day. In samples obtained within the first day of life, total T4 levels are normally lower and TSH levels are normally higher (up to 50 IU/L) and will be reported as abnormal on the newborn screen.
What should I do if the screening test result is "borderline"?
You should check the TSH and total or free T4 level to confirm the diagnosis of congenital hypothyroidism. You should send this sample to a clinical laboratory to obtain an accurate value rather than sending the sample again to the newborn screening lab. It is at your discretion whether to start thyroid hormone replacement therapy immediately or wait until the laboratory results return and the diagnosis is confirmed.
Some newborn screens report a low T4 low but a normal TSH level. What does this mean?
There are many causes of a low total T4 level and a normal TSH level.
- Premature infants commonly have lower T4 levels.
- Sick infants may also have lower T4 levels due to sick euthyroid syndrome.
- In TBG deficiency, total T4 levels are low but free T4 levels are normal. Infants with TBG deficiency are normal and do not need to be treated with thyroid hormone.
- In central hypothyroidism, the TSH level is low to normal and both the total and free T4 levels are low. Before starting thyroid hormone replacement therapy for central hypothyroidism, you should consult with a pediatric endocrinologist.
What should I do in the above situation if the T4 is low and the TSH is normal?
You should check the TSH and free T4 levels to distinguish between TBG deficiency and central hypothyroidism. If the free T4 level is low, contact a pediatric endocrinologist for further advice.
Why is there a second newborn screen?
The newborn screening program was initially designed for infants who were discharged after 3 days in the hospital. With shortened nursery stays, there is a risk for missing some cases of hypothyroidism and the second screen was initiated. A recent study of Colorado's newborn screening program indicates that more than 10% of infants with congenital hypothyroidism are missed by the first screen.
Does this baby need to see a pediatric endocrinologist?
If the infant has a confirmed diagnosis of congenital hypothyroidism, consultation with a pediatric endocrinologist is strongly encouraged. A pediatric endocrinologist can provide expert information to the parents about congenital hypothyroidism and the importance of thyroid hormone replacement to prevent mental retardation. Thyroid function will need to be reassessed throughout infancy and thyroid hormone doses will need to be adjusted as the infant grows. All infants with evidence suggesting central hypothyroidism should be evaluated by a pediatric endocrinologist to assess for associated hormonal abnormalities.