Children's Hospital Colorado

Research at the Heart Institute

At Children's Hospital Colorado, we believe that every child deserves to have a happy, healthy future. Child health research and innovation is at the core of our commitment to deliver the best clinical care for kids. With each patient we see, our physicians and caregivers seek to improve outcomes and deliver world-class care.

Dr. Dunbar Ivy Listens to a toddler's heart while the child plays with a toy car.
Research article

Dr. Dunbar Ivy is part of a select group of PH experts on the forefront of clinical trials, research and treatment.

Cardiology and heart surgery advancements

The Heart Institute includes a team of clinical and basic science researchers focused on improving the understanding and treatment of heart disease. Here are some highlights of our team's innovative work and research projects:

  • Our interventional cardiologists were among the first to use minimally invasive heart catheters to reach and repair heart defects in children.
  • Our pulmonary hypertension (PH) researchers are conducting a five-year study to improve the diagnosis and treatment of PH in children. This study uses 200 patient-specific computer models created to mimic blood flow and biomechanics of the pulmonary system of infants and children.
  • Our surgeons are involved in studies to determine the best surgical techniques to minimize the adverse effects of cardiac surgery and maximize the long-term benefit to children and adults.
  • Our organ and heart transplant research has led to new ways of using the immune system to reduce the likelihood of the body rejecting a transplanted heart.

"Kids deserve focused study. We shouldn’t just rely on what is known to occur in adults; you have to study children just as carefully, just as intensely, as you study adult disease."

Shelley Miyamoto, MD

Director, Cardiomyopathy Program

Learn about Dr. Miyamoto's research

What our heart research means for kids

The Heart Institute is actively engaged in research to determine the best ways to take care of children with congenital or acquired heart disease. There are approximately 75 research studies occurring within the Heart Institute with more than half that are actively enrolling. These studies range from examining cells in the heart to clinical trials of new medications or devices used to treat heart problems in kids.

Funding for the Heart Institute research portfolio comes from many different sources, including grants, industry departments, internal awards, and from the department itself. The Heart Institute is eternally thankful for all the children and families who choose to participate in research. Without them, we would not be able to learn the best ways to take care of kids with congenital or acquired heart disease.

A national leader in congenital heart disease research

The Heart Institute at Children’s Colorado is also part of the National Pediatric Cardiology Quality Improvement Collaborative, an initiative to improve outcomes for kids with congenital heart disease. This allows us to work with many other national pediatric cardiology and cardiac surgery centers to share information and improve the quality of life for kids with single ventricle cardiac anatomy.

See why our outcomes make us one of the top heart hospitals
Jaden Senn shows off the "tough guy" scar from his Fontan operation.

Fontan procedure innovation at the Single Ventricle Clinic

Children who undergo the Fontan procedure often outgrow the materials used in reconstructive surgeries. But regenerative medicine may change that.

Stay informed