Children's Hospital Colorado

Research at the Center for Children's Surgery

Our comprehensive Surgical Center at Children's Hospital Colorado offers the most innovative care for every surgical intervention, thanks to rigorous research initiatives designed to explore diagnostic and treatment approaches that will deliver the best possible outcomes for kids. Because our team is diverse — from a range of surgical specialties, to board-certified pediatric anesthesiologists, to respiratory therapists, child life specialists, pediatric nurses and more — our research efforts are, too.

Physician talking with mother and son
Research article

Due to his medical conditions, LaShawn was highly sensitized. His antibody level was so high that it was delaying the double transplant surgery he needed to survive. Learn about the plan these doctors devised and how they carried it out.

Professional photo of Dr. Kenneth Liechty
Research summary
Picture of Dr. Liechty and another person looking at research study results on a computer screen
Research summary
Clinical trial

Researchers at Children’s Hospital Colorado are investigating the safety and feasibility of providing regenerative therapy for a rare congenital heart defect called hypoplastic left heart syndrome (HLHS).

Infants diagnosed with hypoplastic left heart syndrome in utero
Stem cell collection at birth; Glenn procedure at 3-6 months old

Center for Children's Surgery advancements

Our current projects explore gene therapy, wound healing physiology, the diagnostic and treatment possibilities of big data and many more. We strive to develop and utilize treatment methods that minimize invasiveness and maximize benefit, continually pushing for better, more effective care. These advances not only help patients heal, they save lives.

"The Center for Children's Surgery has NIH-funded surgeon scientists researching all aspects of care, from the laboratory bench to the bedside."
Duncan Wilcox, MD

Cerium oxide nanoparticle therapy for diabetic wounds

Despite the current therapies for chronic wounds in diabetic patients, a significant number of wounds fail to heal. In this study, our researchers targeted two key aspects of non-healing diabetic wounds – chronic inflammation and high oxidative stress – by applying cerium oxide nanoparticles (CNP) as a novel therapeutic agent. Our data showed that local treatment of the diabetic wound with CNP-miR146a resulted in improved healing of diabetic wounds without impairing the biomechanical properties of the skin post-healing. This demonstrates that CNP-miR146a therapy has potentially far-reaching implications for diabetic wound healing research.

Read our article "Use of Cerium Oxide Nanoparticles Conjugated with MicroRNA-146a to Correct the Diabetic Wound Healing Impairment"

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