Research at the Center for Cancer and Blood Disorders
At the Center for Cancer and Blood Disorders, discoveries from our laboratories are changing the way care is delivered for pediatric hematology, oncology and bone marrow transplants.
Our scientists are recognized as national leaders in basic and clinical science research and have funding to support their research from numerous national hematology and oncology foundations.
Advancing Treatment for Pediatric Craniopharyngioma (ATPC) is North America’s first multicenter consortium dedicated exclusively to the discovery and testing of novel therapies for children with adamantinomatous craniopharyngioma (ACP).
The goal of the study is to identify biologically rational therapeutics for the medical treatment of adamantinomatous craniopharyngioma by confirming the overexpression of specific molecules and ultimately improving treatment for patients with this rare tumor.
- Patients with the diagnosis or clinical suspicion of craniopharyngioma in whom planned clinical management will include tissue sampling
- 0-21 years of age
Our oncology and hematology advances
We believe that state-of-the-art treatment for pediatric cancer and blood disorders typically includes enrollment in a clinical trial. In fact, research shows that children who participate in clinical trials have better survival rates than children who do not.
Our physicians and nurses collaborate with laboratory researchers to find new cures and better cancer treatment. Some of our team's most significant advancements include:
- Our physicians discovered new genes important in cancer, and we are using this knowledge to develop new drugs and treatment protocols that more specifically and effectively kill cancer cells. We identified new cancer targets for brain cancer, acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).
- Lia Gore, MD, the leader of our Experimental Therapeutics Program, co-founded the Pediatric Oncology Experimental Therapeutics Investigators Consortium (POETIC), which often expands local clinical trials to children and adolescents across the country.
- Clinical research by a team at our Hemophilia and Thrombosis Center revolutionized the care of children with hemophilia. The researchers transitioned the focus from treatment to prevention of life-threatening and debilitating bleeding episodes through regular home administration of clotting factors.
- Hematology researchers identified the gene that causes grey platelet syndrome, a discovery that will now be used to set the foundation of care for newly diagnosed patients.
"Treatment for autoimmune diseases involves manipulating the same cells we're manipulating for cancer treatment."
Terry J. Fry, MD, pediatric hematologist
Director of Cancer Immunotherapy
Learn about Dr. Fry's research
What our cancer and blood disorder research means for kids
Physicians at the Center for Cancer and Blood Disorders have a variety of interests in clinical, translational and laboratory research. Our major focus areas include:
- Clinical trials for children with all types of cancer
- New cancer therapies
- Sickle cell disease
- Hemophilia and clotting disorders
- Redirecting the immune system
- Different modes of bone marrow transplantation
Our translational and basic laboratory research includes:
- Pediatric leukemia and neuro-oncology biology and genetics
- New molecularly targeted therapies for various types of cancer
- Genetic studies of von Willebrand disease
- Immunotherapy with T cells and NK cells
Our faculty collaborates with international consortiums, laboratory researchers and the University of Colorado Cancer Center to find new cures and better cancer treatments for children.
We also participate in every major pediatric cooperative group for cancer and blood disorders, including:
Learn more about the Center for Cancer and Blood Disorders.
Children's Colorado in the news
September 9, 2017
When Carter was 7 years old, he was diagnosed with a rare form of leukemia. At age 9, he began a craft sale called "Crafts for Cancer" to help raise awareness for childhood cancer. Now 11, Carter has raised more than $5,200.
July 31, 2017
Researchers have found a cure for nearly every childhood cancer. In Colorado, students are joining scientists to tackle that rare cancer; an aggressive tumor of the brain stem called diffuse intrinsic pontine glioma (DIPG).
June 27, 2017
Jason Kotas, shared his journey through childhood cancer and how, with the right planning, he and wife, Emily, were able to welcome their first child.
May 5, 2017
The Center for Cancer and Blood Disorders (CCBD) hosted the 7th Annual Celebration of Life event and honored pediatric cancer survivors and family members living with and beyond cancer. The event was held at Wings Over the Rockies museum and hundreds of past and current patients of the H.O.P.E. (Helping Oncology Patients Excel) Survivorship Program attended.